Tartary Buckwheat Extracts Regulate Insulin Sensitivity through IKKβ/IR/IRS-1/Akt Pathway under Inflammation Condition in Mice

Tartary buckwheat is rich in flavonoids which have positive effects on preventing chronic disease. But the mechanism of tartary buckwheat ameliorating chronic disease is still poorly understood. This study investigated the regulation of insulin action in skeletal muscle by tartary buckwheat extracts (TBE) under inflammation states in mice. In mice with insulin resistance, glucose intolerance and insulin intolerance was reversed and muscular and hepatic glycogen levels were significantly increased by oral administration of TBE. Furthermore, TBE inhibited inflammation-stimulated IKKβ activation and IRS-1 serine phosphorylation in skeletal muscle tissue, and effectively facilitated IRS-1 tyrosine and downstream molecule Akt phosphorylation, leading to an increase in insulin-mediated glucose uptake in skeletal muscle tissue. The results showed that TBE modulated positively the phosphorylation of IRS-1 function in inflammatory condition to regulation the insulin sensitivity.